Search

Biological and Medicinal Chemistry

Working Paper

Fluorescent Ligand Enables Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2

Max Huber, Silas Wurnig, Lara Toy, Corinna Weiler, Nicole Merten, Evi Kostenis, Finn Hansen, Matthias Schiedel

Version 4 posted 28 April 2023

392

Downloads

Biological and Medicinal Chemistry

Working Paper

Biology-directed and in silico-aided design liberates a potent, simplified and ipomoeassin-F-derived Sec61 inhibitor

Sarah O'Keefe, Pratiti Bhadra, Kwabena Duah, Guanghui Zong, Levise Tenay, Lauren Andrews, Hayden Schneider, Ashley Anderson, Zhijian Hu, Hazim Aljewari, Belinda Hall, Rachel Simmonds, Volkhard Helms, Stephen High, Wei Shi

Version 1 posted 04 March 2022

221

Downloads

Biological and Medicinal Chemistry

Working Paper

The most common linkers in bioactive molecules and their bioisosteric replacement network

Peter Ertl, Eva Altmann, Sophie Racine

Version 1 posted 30 November 2022

1,426

Downloads

Organic Chemistry

Working Paper

General and Scalable Approach to Trifluoromethyl-substituted Cyclopropanes

Pavel Mykhailiuk, Volodymyr Ahunovych, Anton Klipkov, Maksym Bugera, Karen Tarasenko, Serhii Trofymchuk, Oleh Stanko, Andrii Boretskyi, Mykola Zheludenko, Iryna Sadkova

Version 1 posted 18 January 2023

1,130

Downloads

1

Citations

Biological and Medicinal Chemistry

Review

New Antitumor Organotitanium Complexes with a Pendant Biologically Active Diazo Group

Gregory Arzoumanidis

Version 1 posted 12 August 2022

158

Downloads

Organic Chemistry

Working Paper

A New Reagent to Access Methyl Sulfones

Pavel K. Mykhailiuk, Yaroslav Poplavsky, Vasyl Ripenko, Sergei Bova, Angelina Biitseva, Yurii V. Dmitriv, Andrei A. Tolmachev, Iryna V. Sadkova, Vo Quang Huy Phan, H. V. Rasika Dias

Version 1 posted 17 April 2024

1,910

Downloads

Biological and Medicinal Chemistry

Working Paper

The discovery of high affinity and metabolically stable allosteric cyclin-dependent kinase 2 (CDK2) inhibitors from screening through lead optimization

Erik B. Faber, Nan Wang, Kristen John, Luxin Sun, David Burban, Henry L. Wong, Rawle Francis, Defeng Tian, Kwon H. Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas Levinson, Ernst Schönbrunn, Jon E. Hawkinson, Gunda Georg

Version 2 posted 18 August 2022

796

Downloads

Refine Search

7 results in Medicinal Chemistry in Keywords: Medicinal Chemistry

Fluorescent Ligand Enables Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2

Biology-directed and in silico-aided design liberates a potent, simplified and ipomoeassin-F-derived Sec61 inhibitor

The most common linkers in bioactive molecules and their bioisosteric replacement network

General and Scalable Approach to Trifluoromethyl-substituted Cyclopropanes

New Antitumor Organotitanium Complexes with a Pendant Biologically Active Diazo Group

A New Reagent to Access Methyl Sulfones

The discovery of high affinity and metabolically stable allosteric cyclin-dependent kinase 2 (CDK2) inhibitors from screening through lead optimization

7 results in Keywords: Medicinal Chemistry