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Biological and Medicinal Chemistry

Working Paper

Enzyme-Catalysed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis

Oksana Bilyk, Finian Leeper, Marcio Vinicius Bertacine Dias, Peter Leadlay

Version 1 posted 25 March 2022

271

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Biological and Medicinal Chemistry

Working Paper

Inhibition of Thiamine Diphosphate (ThDP)-dependent Enzymes by Triazole-based Thiamine Analogues

Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rebecca Pope, Kevin J. Saliba, Finian James Leeper

Version 1 posted 25 January 2023

146

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Biological and Medicinal Chemistry

Working Paper

Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase

Alex H. Y. Chan, Terence C. S. Ho, Kwasi Agyei-Owusu, Finian James Leeper

Version 1 posted 06 October 2022

107

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Biological and Medicinal Chemistry

Working Paper

The structural and functional basis of GenB2 isomerase activity from gentamicin biosynthesis

Gabriel de Oliveira, Priscila Bury, Fanglu Huang, Yuan Li, Natália Araújo, Jiahai Zhou, Yuhui Sun, Finian Leeper, Peter Leadlay, Marcio Dias

Version 1 posted 16 April 2024

61

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Biological and Medicinal Chemistry

Working Paper

Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes

Alex H. Y. Chan, Terence C. S. Ho, Finian James Leeper

Version 1 posted 30 May 2023

79

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Biological and Medicinal Chemistry

Working Paper

Thiamine Analogues as Tools to Study Pyruvate Dehydrogenase in Cancer: Biochemical, Computational and Cellular Analyses

Finian James Leeper, Alex Chan, Terence Ho, Daniel Parle

Version 1 posted 19 September 2022

185

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1

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Biological and Medicinal Chemistry

Working Paper

Evaluation of Ketoclomazone and its Analogues as Inhibitors of Thiamine Diphosphate (ThDP)-dependent Enzymes

Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rawia Hamid, Anna K. H. Hirsch, Kevin J. Saliba, Finian James Leeper

Version 1 posted 17 January 2024

84

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Biological and Medicinal Chemistry

Working Paper

Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding

Terence C. S. Ho, Alex H. Y. Chan, Finian James Leeper

Version 1 posted 09 May 2024

29

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Biological and Medicinal Chemistry

Working Paper

Strategies on Designing Thiamine Analogues for Inhibition of Thiamine Diphosphate (ThDP)-dependent Enzymes: Systematic Investigation through Scaffold Switching and C2-Functionalisation

Alex H. Y. Chan, Terence C. S. Ho, Rimsha Irfan, Rawia A. A. Hamid, Emma S. Rudge, Amjid Iqbal, Alex Turner, Anna K. H. Hirsch, Finian James Leeper

Version 2 posted 20 February 2023

191

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9 results in Finian Leeper in Authors: Finian Leeper

Enzyme-Catalysed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis

Inhibition of Thiamine Diphosphate (ThDP)-dependent Enzymes by Triazole-based Thiamine Analogues

Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase

The structural and functional basis of GenB2 isomerase activity from gentamicin biosynthesis

Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes

Thiamine Analogues as Tools to Study Pyruvate Dehydrogenase in Cancer: Biochemical, Computational and Cellular Analyses

Evaluation of Ketoclomazone and its Analogues as Inhibitors of Thiamine Diphosphate (ThDP)-dependent Enzymes

Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding

Strategies on Designing Thiamine Analogues for Inhibition of Thiamine Diphosphate (ThDP)-dependent Enzymes: Systematic Investigation through Scaffold Switching and C2-Functionalisation

9 results in Authors: Finian Leeper