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Toward Secure Supply of Remdesivir via a 2-Pot Triazine Synthesis: Supply Centered Synthesis

Dinesh J. Paymode, Flavio S. P. Cardoso, Joshua D. Sieber, John W. Tomlin, Daniel W. Cook, Justina Burns, Rodger W. Stringham, B. Frank Gupton, David Snead, Toolika Agrawal

Version 1 posted 10 August 2020

847

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2

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Organic Chemistry

Working Paper

Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium

Jule-Phillip Dietz, Tobias Lucas, Jonathan Groß, Sebastian Seitel, Jan Brauer, Dorota Ferenc, B. Frank Gupton, Till Opatz

Version 1 posted 13 April 2021

1,015

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Organic Chemistry

Working Paper

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

Brenden Derstine, John W. Tomlin, Cheryl Peck, Jule-Phillip Dietz, Brenden Herrera, Flavio S. P. Cardoso, Dinesh J. Paymode, Andrew C. Yue, Anthony J. Arduengo III, Till Opatz, David R. Snead, Rodger W. Stringham, D. Tyler McQuade, B. Frank Gupton

Version 1 posted 26 February 2020

2,044

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Organic Chemistry

Working Paper

A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

Vijayagopal Gopalsamuthiram, Corshai Williams, Jeffrey Noble, Timothy F. Jamison, B. Frank Gupton, David Snead

Version 1 posted 09 September 2020

1,505

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Organic Chemistry

Working Paper

Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint Driven Innovation

Komirishetty Kashinath, David Snead, Justina Burns, Rodger W. Stringham, B. Frank Gupton, D. Tyler McQuade

Version 1 posted 02 April 2020

697

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Organic Chemistry

Working Paper

A Concise Route to MK-4482 (EIDD-2801)

Natarajan Vasudevan, Grace P. Ahlqvist, Catherine P. McGeough, Dinesh J. Paymode, Flavio S. P. Cardoso, Tobias Lucas, Jule-Phillip Dietz, Till Opatz, Timothy F. Jamison, B. Frank Gupton, David Snead

Version 1 posted 19 August 2020

1,394

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Organic Chemistry

Working Paper

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir

Sarabindu Roy, Ajay Yadaw, Subho Roy, Gopal Sirasani, Joseph D. Armstrong, B. Frank Gupton, Chris Senanayake, David Snead

Version 1 posted 25 February 2021

646

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1

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Organic Chemistry

Working Paper

The Di-Tert-Butyl Oxymethylphosphonate Route to the Antiviral Drug Tenofovir

Jule-Phillip Dietz, Dorota Ferenc, Timothy F. Jamison, B. Frank Gupton, Till Opatz

Version 1 posted 16 September 2020

562

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Organic Chemistry

Working Paper

Efforts to Develop a Cost-Effective and Scalable Synthetic Process for Nirmatrelvir

Charles S. Shanahan, Appasaheb L. Kadam, Barreddi Chiranjeevi, Aline A. Nunes, Aravindan Jayaraman, Saeed Ahmad, Sarah L. Aleshire, Kai O. Donsbach, B. Frank Gupton, Michel C. Nuckols

Version 1 posted 08 August 2022

930

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5

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Organic Chemistry

Working Paper

Towards a Practical, Non-enzymatic Process for Molnupiravir from Cytidine

Vijayagopal Gopalsamuthiram, Appasaheb L. Kadam, Jeffrey Noble, David Snead, Corshai Williams, Timothy F. Jamison, Chris Senanayake, Ajay Yadaw, Sarabindu Roy, Gopal Sirasani, B. Frank Gupton, Justina Burns, Daniel W. Cook, Rodger W. Stringham, Saeed Ahmad, Rudy Krack

Version 1 posted 08 June 2021

2,212

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2

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12 results in B. Frank Gupton in Authors: B. Frank Gupton

Toward Secure Supply of Remdesivir via a 2-Pot Triazine Synthesis: Supply Centered Synthesis

Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint Driven Innovation

A Concise Route to MK-4482 (EIDD-2801)

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir

The Di-Tert-Butyl Oxymethylphosphonate Route to the Antiviral Drug Tenofovir

Efforts to Develop a Cost-Effective and Scalable Synthetic Process for Nirmatrelvir

Towards a Practical, Non-enzymatic Process for Molnupiravir from Cytidine

12 results in Authors: B. Frank Gupton