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Abstract
Herein, we report the high yielding solid-phase synthesis of unmodified and chemically modified trinucleotide triphosphates (dN3TPs). These synthetic codons can be used for enzymatic DNA synthesis provided their scaffold is stabilized with phosphorothioate units. Enzymatic synthesis with three rather than one letter nucleotides will be useful for the production of xenonucleic acids (XNAs) and for in vitro selection of modified functional nucleic acids.
Supplementary materials
Title
Artificial nucleotide codons for enzymatic DNA synthesis
Description
Supporting Information
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