Visible Light Induced Catalyst-free Deaminative C-2 Alkylation of Heterocyclic-N-Oxides using Katritzky salts.

N-heteroaromatic compounds play a vital role in nature and medicine.1 Among them, quinolines and its functionalized derivatives represent a key component in a variety of biologically active moieties and drug molecules such as quinine, Montelucast, Mefloquine, Vacquinol-1, etc.2 Because of the poor selectivity and reactivity associated with the low-energy -system, direct C-2 functionalization of quinolines is a major challenge in synthetic organic chemistry. To address this problem, the utilization of easily accessible quinoline-N-oxides is an alternate approach where O-directed functionalization of these scaffolds results in excellent regioselectivity. we have demonstrated a mild and efficient EDA driven, visible-light enabled strategy for the synthesis of C-2 alkylated heterocyclic-N-oxides via catalyst-free deamination of Katritzky salts with quinoline-N-oxides. The method provides a mild access to a series of C-2 alkylated quinoline-N-oxide, quinoxaline-N-oxide and pyridine-N-oxide derivatives. Moreover, a series of control experiments elucidated the reaction mechanism.