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Mechanochemical Protocol Facilitates the Generation of Arylmanganese Nucleophiles from Unactivated Manganese Metal

22 August 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report a mechanochemical ball-milling protocol facilitates the generation of various arylmanganese nucleophiles from aryl halides and commercially available manganese metal without the need for complicated pre-activation processes. These manganese-based carbon nucleophiles can be used directly for one-pot addition reactions with various electrophiles and palladium-catalyzed cross-coupling reactions under bulk-solvent-free mechanochemical conditions. Importantly, all experimental operations can be conducted under atmospheric conditions.

Supplementary materials

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Supporting Information
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Experimental procedures and spectroscopic data for synthesized compounds.
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Version History

Aug 22, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-48bnj
D O I: 10.26434/chemrxiv-2022-48bnj [opens in a new tab]

Funding

Japan Society for the Promotion of Science
22H0031802
Japan Society for the Promotion of Science
22H05328
Japan Society for the Promotion of Science
21H01926
Japan Sciences and Technology Agency
JPMJCR19R1
Japan Sciences and Technology Agency
JPMJFR201I

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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