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Non-aqueous bonding of leuprorelin to Ochratoxin A for solid-phase extraction

09 August 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The anticancer leuprorelin was found to have excellent affinity to ochratoxin A (OTA), with an equilibrium constant of 2.2 × 10^8 M^-1 at 273 K (dissociation constant Kd = 4.5 nM) when functionalized into a mesoporous polymer for binding to OTA. Binding between the surface-bound leuprorelin and mycotoxin was corroborated using DFT-based analysis, and it was extended to extraction of OTA from heavily fatty matrices of coffee, achieving 95% recovery with improved cyclability as compared with immunoaffinity.

Keywords

leuprorelin
ochratoxin A
solid-phase extraction
molecular association

Supplementary materials

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Now Published

Non-aqueous bonding of leuprorelin to Ochratoxin A for peptide-based solid-phase extraction [opens in a new tab]
Naoki Yamato, Noriaki Kumagai, Momoha Okahira, Satoru Kosaka, Shuji Kodama, Ryohei Yamamoto, Atsushi Yamamoto, Koichiro Takao, Masanori Yamamoto journal article
Chemical Communications
Online publication date: 2022

Version History

Aug 09, 2022 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-3r8q9
D O I: 10.26434/chemrxiv-2022-3r8q9 [opens in a new tab]

Funding

Japan Society for the Promotion of Science
18K05526

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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