Enantioselective Synthesis of 2-Isoxazolines and 2-Isoxazolin-5-ones Bearing Fully Substituted Stereocenters

08 August 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Although there is an abundance of methods for the enantioselective synthesis of 2-isoxazolines and 2-isoxazolin-5-ones, relatively few of these approaches have been reported when these heterocycles bear fully substituted stereocenters. In this minireview, we will detail the methods that have been used to successfully accomplish these challenging asymmetric transformations and give insights into their importance, such as allowing access to unique three-dimensional chemical space. The limitations of the currently known reactions will be discussed, as well as highlighting the future developments needed to advance the research field.

Keywords

isoxazolines
isoxazolinones
enantioselective synthesis
asymmetric catalysis
organocatalysis

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