Co-Immobilization of Enzymes and Aptamers to create Self-Regenerating Ultrafiltration Membranes for Toxin Removal

Aptamer-functionalized membranes offer a promising platform for toxin removal, but regeneration of binding capacity requires heat and washing. Moreover, bound molecules can be eluted, resulting in recontamination. Here we report the tandem use of aptamers and enzymes to trap and degrade small-molecule contaminants, resulting in an autonomously self-regenerating purification system.