Nickel-catalyzed 1,4-rearrangement of an aryl Group in aryl N-benzylimidates via C–O and C–H bond cleavage

26 April 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report herein that nickel-catalyzed reaction of aryl imidates bearing an N-benzyl group results in 1,4-migration of an O-aryl group via the cleavage of C–O and C–H bonds. This protocol allows for the benzylic C–H bond arylation of benzylamine building blocks using phenols as an aryl source to form elaborate diarylmethylamine derivatives.

Keywords

nickel catalyst
C-O activation
C-H activation

Supplementary materials

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Supporting Information
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Detailed experimental procedures and spectroscopic data for new compounds.
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