Ring-Opening Fluorination of Bicyclic Azaarenes

05 November 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We have discovered a ring-opening fluorination of bicyclic azaarenes. Upon treatment of bicyclic azaarenes such as pyrazolopyridines with electrophilic fluorinating agents, fluorination of the aromatic ring is followed by a ring-opening reaction. Although this overall trans-formation can be classified as an electrophilic fluorination of an aromatic ring, it is a novel type of fluorination that results in construction of tertiary carbon–fluorine bonds. The present protocol can be applied to a range of bicyclic azaarenes, tolerating azines and a variety of functional groups. Additionally, mechanistic studies and enantioselective fluorination have been examined.

Keywords

Fluorination
ring-opening reaction
electrophilic fluorinating agents
azaarenes
Selectfluor

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